Zenascope™ IM1

Zenascope_IM1Based on the Zenascope™ PC1 technology, the Zenascope IM1 product features a multifunction probe (right). The probe’s integrated functions include: send and receive sensor fibers for quantitative VIS spectroscopy, a tissue contact pressure sensor, a two-megapixel video/still camera, and illumination LEDs for both white light and ultraviolet (auto-fluorescence) imaging.

Zenalux offers the Zenascope IM1 in standard and custom configurations.

The standard configuration offers quantitative measurement of [Hb], [HbO2] and scattering. Zenalux assists customers in set up and will monitor initial results to validate measurement response.

Custom configurations include additional absorbers of interest to the customer. Zenalux will customize and validate the Zenascope to include additional absorbers.

The following table lists the optical endpoints provided by Zenascope.

Measured Endpoint Biological Relevance Unit Accuracy
Wavelength averaged Reduced Scattering Cellular density; fibrous content 1/cm ±10%
Total hemoglobin content Vascularity µM ±10%
Hemoglobin saturation Vascular oxygenation N/A ±10%

The screen capture in the figure below illustrates the functionality of the IM1 probe. The dual images at the top of the screen are taken with white light (on the left) and UV light (on the right). The integrated illumination LEDs alternate between white and UV light (about 2x per second) and are synchronized with image capture. The result is a real-time video display (normal resolution only) of simultaneous white and UV light images taken from nearly identical vantage points. Controls on the upper right allow manual image capture and saving along with enabling and disabling white and UV illumination and imaging. Additional controls include LED brightness, camera color balance, and toggling between normal and high definition image modes.


The strip chart on the lower right displays the results of multiple endpoint readings taken of a single-use session for the sample. The numeric displays on the lower left show the quantitative endpoint measurements for the most recent data capture. The bar display, lower center, indicates the real-time contact pressure between the probe tip and the tissue under examination. Controls on the upper right allow the user to set under and over pressure thresholds and to activate or disable automatic data capture when the probe-to-tissue contact is within the target range.

Data captured for a reading includes time stamp, operator-provided patient identifiers and notes, snapshots of the video stream (white and UV), pressure readings, raw spectral data, and the quantitative measurements of the defined endpoints.

Pre-clinical and clinical studies have demonstrated the efficacy of this quantitative diagnostic technique both in vivo and ex vivo. Application areas that have been researched thus far include accelerating feedback in drug discovery; breast tumor margin assessment; breast biopsy; cervical cancer; and head and neck cancer detection.

The Zenascope products are designated for pre-clinical use at this time.